He is an Egyptian director and scriptwriter, born to a famous father, Director Salah Abu Seif. Although he is a graduate of the American University in Cairo, Department of Psychology in 1972, Mohamed wanted to be like his dad so he studied directing at the High Cinema Institute and graduated in 1976. He worked with several directors as an assistant director, including his dad in the movie The Bathhouse of Malatily (1973), then directed his attention to commercial advertising. His first movie ever was The Apple and the Skull.

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